Open AccessReduced Daily Risk of Glycemic Variability: Comparison of Exenatide with Insulin Glargine
Author(s) -
Anthony L. McCall,
Daniel J. Cox,
Robert G. Brodows,
John Crean,
Don Johns,
Boris Kovatchev
Publication year - 2009
Publication title -
diabetes technology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.142
H-Index - 88
eISSN - 1557-8593
pISSN - 1520-9156
DOI - 10.1089/dia.2008.0107
Subject(s) - exenatide , medicine , insulin glargine , glycemic , sulfonylurea , type 2 diabetes , hypoglycemia , diabetes mellitus , endocrinology , insulin
Conventional methods describing daily glycemic variability (i.e., standard deviation and coefficient of variation) do not express risk. Low and High Blood Glucose Indices (LBGI and HBGI, respectively) and Average Daily Risk Range (ADRR) are parameters derived from self-monitored blood glucose (SMBG) data that quantify risk of glycemic excursions and temporal aspects of variability. In the present study, variability parameters were used to assess effects of exenatide and insulin glargine on risk of acute blood glucose extremes.