Open AccessAuditing the Editor: A Review of Key Translational Issues in Epigenetic Editing
Author(s) -
Katherine Huerne,
Nicole Palmour,
Sean M. Wu,
Stephan Beck,
Alison Berner,
Reiner Siebert,
Yann Joly
Publication year - 2022
Publication title -
the crispr journal
Language(s) - English
Resource type - Journals
eISSN - 2573-1602
pISSN - 2573-1599
DOI - 10.1089/crispr.2021.0094
Subject(s) - epigenetics , genome editing , crispr , equity (law) , bench to bedside , context (archaeology) , engineering ethics , computer science , data science , computational biology , political science , biology , medicine , genetics , engineering , gene , paleontology , law , medical physics
Currently, most advances in site-specific epigenetic editing for human use are concentrated in basic research, yet, there is considerable interest to translate this technology beyond the bench. This review highlights recent developments with epigenetic editing technology in comparison with the canonical CRISPR-Cas genome editing, as well as the epistemic and ethical considerations with preemptive translation of epigenetic editing into clinical or commercial use in humans. Key considerations in safety, equity, and access to epigenetic editing are highlighted, with a spotlight on the ethical, legal, and social issues of this technology in the context of global health equity.