Open AccessRational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects
Author(s) -
Zhicheng Zuo,
Kesavan Babu,
Chhandosee Ganguly,
Ashwini Zolekar,
Sydney Newsom,
Rakhi Rajan,
Yu-Chieh Wang,
Jin Liu
Publication year - 2022
Publication title -
the crispr journal
Language(s) - English
Resource type - Journals
eISSN - 2573-1602
pISSN - 2573-1599
DOI - 10.1089/crispr.2021.0076
Subject(s) - cas9 , crispr , nuclease , genome editing , guide rna , computational biology , dna , rational design , gene , biology , protein engineering , rna , microbiology and biotechnology , genetics , enzyme , biochemistry
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