CRISPR-Cas Activators for Engineering Gene Expression in Higher Eukaryotes | Zendy

J. Armando Casas-Mollano | Zendy; Matthew H. Zinselmeier | Zendy; Samuel E. Erickson | Zendy; Michael J. Smanski | Zendy

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CRISPR-Cas Activators for Engineering Gene Expression in Higher Eukaryotes

Author(s) -

J. Armando Casas-Mollano,

Matthew H. Zinselmeier,

Samuel E. Erickson,

Michael J. Smanski

Publication year - 2020

Publication title -

the crispr journal

Language(s) - English

Resource type - Journals

eISSN - 2573-1602

pISSN - 2573-1599

DOI - 10.1089/crispr.2020.0064

Subject(s) - crispr , computational biology , gene , genome editing , gene expression , genome engineering , biology , regulation of gene expression , synthetic biology , genetics

CRISPR-Cas-based transcriptional activators allow genetic engineers to specifically induce expression of one or many target genes in trans . Here we review the many design variations of these versatile tools and compare their effectiveness in different eukaryotic systems. Lastly, we highlight several applications of programmable transcriptional activation to interrogate and engineer complex biological processes.

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