Randomized Double-Blind Placebo-Controlled Trial of Lithium in Youths with Severe Mood Dysregulation | Zendy

Daniel P. Dickstein | Zendy; Kenneth E. Towbin | Zendy; Jan Willem van der Veen | Zendy; Brendan A. Rich | Zendy; Melissa A. Brotman | Zendy; Lisa Knopf | Zendy; Laura Onelio | Zendy; Daniel S. Pine | Zendy; Ellen Leibenluft | Zendy

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Randomized Double-Blind Placebo-Controlled Trial of Lithium in Youths with Severe Mood Dysregulation

Author(s) -

Daniel P. Dickstein,

Kenneth E. Towbin,

Jan Willem van der Veen,

Brendan A. Rich,

Melissa A. Brotman,

Lisa Knopf,

Laura Onelio,

Daniel S. Pine,

Ellen Leibenluft

Publication year - 2009

Publication title -

journal of child and adolescent psychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.935

H-Index - 84

eISSN - 1557-8992

pISSN - 1044-5463

DOI - 10.1089/cap.2008.044

Subject(s) - irritability , placebo , randomized controlled trial , medicine , lithium (medication) , psychology , mood , clinical trial , psychiatry , physical therapy , alternative medicine , menopause , pathology

The diagnosis and treatment of youth with severe nonepisodic irritability and hyperarousal, a syndrome defined as severe mood dysregulation (SMD) by Leibenluft, has been the focus of increasing concern. We conducted the first randomized double-blind, placebo-controlled trial in SMD youth, choosing lithium on the basis of its potential in treating irritability and aggression and neuro-metabolic effects.

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