Open AccessRandomized Double-Blind Placebo-Controlled Trial of Lithium in Youths with Severe Mood Dysregulation
Author(s) -
Daniel P. Dickstein,
Kenneth E. Towbin,
Jan Willem van der Veen,
Brendan A. Rich,
Melissa A. Brotman,
Lisa Knopf,
Laura Onelio,
Daniel S. Pine,
Ellen Leibenluft
Publication year - 2009
Publication title -
journal of child and adolescent psychopharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 84
eISSN - 1557-8992
pISSN - 1044-5463
DOI - 10.1089/cap.2008.044
Subject(s) - irritability , placebo , randomized controlled trial , medicine , lithium (medication) , psychology , mood , clinical trial , psychiatry , physical therapy , alternative medicine , menopause , pathology
The diagnosis and treatment of youth with severe nonepisodic irritability and hyperarousal, a syndrome defined as severe mood dysregulation (SMD) by Leibenluft, has been the focus of increasing concern. We conducted the first randomized double-blind, placebo-controlled trial in SMD youth, choosing lithium on the basis of its potential in treating irritability and aggression and neuro-metabolic effects.