Open AccessNano-Pulse Stimulation Therapy for the Treatment of Skin Lesions
Author(s) -
Richard Nuccitelli
Publication year - 2019
Publication title -
bioelectricity
Language(s) - English
Resource type - Journals
eISSN - 2576-3113
pISSN - 2576-3105
DOI - 10.1089/bioe.2019.0027
Subject(s) - dermis , clearance , medicine , hyperplasia , stimulation , biomedical engineering , epidermis (zoology) , photothermal therapy , dermatology , chemistry , pathology , materials science , nanotechnology , urology , anatomy
Nano-Pulse Stimulation (NPS) therapy applies nanosecond pulsed electric fields to cells and tissues. It is a nonthermal modality that uses ultrashort pulses of electrical energy in the nanosecond domain. The cellular response to this therapy can be quite varied depending on the number of pulses applied and the total energy delivered. Reviewed in this study are some clinical trial data describing the effects of NPS therapy on normal skin as well as three different skin lesions as part of the first commercial application of this technology. NPS therapy has been found to clear seborrheic keratosis lesions with an 82% efficacy and sebaceous gland hyperplasia with a 99.5% efficacy. Pilot studies on warts indicated that 60% of the NPS-treated warts were completely cleared within 60 days. NPS therapy can be used to treat cellular lesions in the epidermis and dermis without affecting noncellular components such as collagen and fibrin.