Open AccessThe Interplay Between Systemic Inflammation, Oxidative Stress, and Tissue Remodeling in Tuberculosis
Author(s) -
Eduardo P. Amaral,
Caian L. Vinhaes,
Deivide Oliveira-de-Souza,
Betânia M. F. Nogueira,
Kevan Akrami,
Bruno B. Andrade
Publication year - 2021
Publication title -
antioxidants and redox signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.277
H-Index - 190
eISSN - 1557-7716
pISSN - 1523-0864
DOI - 10.1089/ars.2020.8124
Subject(s) - oxidative stress , inflammation , proinflammatory cytokine , immunology , tuberculosis , tissue remodeling , medicine , exacerbation , immune system , disease , pathology
Significance: Excessive and prolonged proinflammatory responses are associated with oxidative stress, which is commonly observed during chronic tuberculosis (TB). Such condition favors tissue destruction and consequently bacterial spread. A tissue remodeling program is also triggered in chronically inflamed sites, facilitating a wide spectrum of clinical manifestations. Recent Advances: Since persistent and exacerbated oxidative stress responses have been associated with severe pathology, a number of studies have suggested that the inhibition of this augmented stress response by improving host antioxidant status may represent a reasonable strategy to ameliorate tissue damage in TB. Critical Issues: This review summarizes the interplay between oxidative stress, systemic inflammation and tissue remodeling, and its consequences in promoting TB disease. We emphasize the most important mechanisms associated with stress responses that contribute to the progression of TB. We also point out important host immune components that may influence the exacerbation of cellular stress and the subsequent tissue injury. Future Directions: Further research should reveal valuable targets for host-directed therapy of TB, preventing development of severe immunopathology and disease progression. Antioxid. Redox Signal. 34, 471-485.