Open AccessRedox Signaling Through Compartmentalization of Reactive Oxygen Species: Implications for Health and Disease
Author(s) -
Andrew P. Wojtovich,
Brandon J. Berry,
Alexander Galkin
Publication year - 2019
Publication title -
antioxidants and redox signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.277
H-Index - 190
eISSN - 1557-7716
pISSN - 1523-0864
DOI - 10.1089/ars.2019.7804
Subject(s) - compartmentalization (fire protection) , reactive oxygen species , redox , microbiology and biotechnology , disease , oxygen , chemistry , biology , biochemistry , enzyme , medicine , pathology , organic chemistry
The cell maintains a balance between the production and removal of reactive oxygen species (ROS). Changes in ROS levels can impact many cellular functions, and dysregulation contributes to pathologies. How a specific cellular environment or microdomain influences the ROS-generating systems and biological impact of ROS remains an active area of research. This Forum highlights the complexity of ROS microdomains and their contributions to health and disease. Novel technologies to measure or generate ROS in defined regions are important developments in the spatial control of ROS. Using these advances, the articles herein demonstrate how site-specific redox environments influence cellular function and pathology. Antioxid. Redox Signal. 31, 591-593.