The Fibrosis of Chronic Pancreatitis: New Insights into the Role of Pancreatic Stellate Cells | Zendy

Minoti V. Apte | Zendy; Romano C. Pirola | Zendy; Jeremy S. Wilson | Zendy

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The Fibrosis of Chronic Pancreatitis: New Insights into the Role of Pancreatic Stellate Cells

Author(s) -

Minoti V. Apte,

Romano C. Pirola,

Jeremy S. Wilson

Publication year - 2011

Publication title -

antioxidants and redox signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.277

H-Index - 190

eISSN - 1557-7716

pISSN - 1523-0864

DOI - 10.1089/ars.2011.4079

Subject(s) - pancreatitis , hepatic stellate cell , fibrosis , pancreas , pancreatic cancer , medicine , extracellular matrix , cancer research , bioinformatics , biology , pathology , microbiology and biotechnology , cancer

Prominent fibrosis is a major histological feature of chronic pancreatitis, a progressive necroinflammatory condition of the pancreas, most commonly associated with alcohol abuse. Patients with this disease often develop exocrine and endocrine insufficiency characterized by maldigestion and diabetes. Up until just over a decade ago, there was little understanding of the pathogenesis of pancreatic fibrosis in chronic pancreatitis.

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