Open AccessRedox Control of Vascular Smooth Muscle Migration
Author(s) -
Alejandra San Martín,
Kathy K. Griendling
Publication year - 2010
Publication title -
antioxidants and redox signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.277
H-Index - 190
eISSN - 1557-7716
pISSN - 1523-0864
DOI - 10.1089/ars.2009.2852
Subject(s) - microbiology and biotechnology , cell migration , lamellipodium , focal adhesion , motility , vascular smooth muscle , signal transduction , intracellular , biology , actin cytoskeleton , cell , cytoskeleton , extracellular matrix , actin , chemistry , biochemistry , smooth muscle , endocrinology
Vascular smooth muscle cell migration is important during vascular development and contributes to lesion formation in the adult vasculature. The mechanisms regulating migration of this cell type are therefore of great interest. Recent work has shown that reactive oxygen species (ROS) derived from NADPH oxidases are important mediators of promigratory signaling pathways. ROS regulate the intracellular signals responsible for lamellipodia formation, actin cytoskeleton remodeling, focal adhesion turnover, and contraction of the cell body. In addition, they contribute to matrix remodeling, a critical step to initiate and support vascular smooth muscle cell motility. Despite these recent advances in our understanding of the redox mechanisms that contribute to migration, additional work is needed to evaluate fully the potential of ROS-sensitive molecular signals as therapeutic targets to prevent inappropriate smooth muscle cell migration.