Open AccessImproving the Youth HIV Prevention and Care Cascades: Innovative Designs in the Adolescent Trials Network for HIV/AIDS Interventions
Author(s) -
Sylvie Naar,
Michael G. Hudgens,
Ron Brookmeyer,
April Idalski Carcone,
Jason E. Chapman,
Shrabanti Chowdhury,
Andrea Ciaranello,
W. Scott Comulada,
Samiran Ghosh,
Keith J. Horvath,
LaDrea Ingram,
Sara LeGrand,
Cathy J. Reback,
Kit N. Simpson,
Bonita Stanton,
Tyrel J. Starks,
Dallas Swendeman
Publication year - 2019
Publication title -
aids patient care and stds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.504
H-Index - 85
eISSN - 1557-7449
pISSN - 1087-2914
DOI - 10.1089/apc.2019.0095
Subject(s) - psychological intervention , medicine , human immunodeficiency virus (hiv) , rigour , protocol (science) , pre exposure prophylaxis , resource (disambiguation) , clinical trial , family medicine , alternative medicine , nursing , computer science , men who have sex with men , computer network , geometry , mathematics , pathology , syphilis
Dramatic decreases in HIV transmission are achievable with currently available biomedical and behavioral interventions, including antiretroviral therapy and pre-exposure prophylaxis. However, such decreases have not yet been realized among adolescents and young adults. The Adolescent Medicine Trials Network (ATN) for HIV/AIDS interventions is dedicated to research addressing the needs of youth at high risk for HIV acquisition as well as youth living with HIV. This article provides an overview of an array of efficient and effective designs across the translational spectrum that are utilized within the ATN. These designs maximize methodological rigor and real-world applicability of findings while minimizing resource use. Implementation science and cost-effectiveness methods are included. Utilizing protocol examples, we demonstrate the feasibility of such designs to balance rigor and relevance to shorten the science-to-practice gap and improve the youth HIV prevention and care continua.