Open AccessProviding Adverse Outcome Pathways from the AOP-Wiki in a Semantic Web Format to Increase Usability and Accessibility of the Content
Author(s) -
Marvin Martens,
Chris T. Evelo,
Egon Willighagen
Publication year - 2022
Publication title -
applied in vitro toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 9
eISSN - 2332-1539
pISSN - 2332-1512
DOI - 10.1089/aivt.2021.0010
Subject(s) - computer science , sparql , rdf , ontology , workflow , information retrieval , world wide web , database , semantic web , usability , rdf schema , resource (disambiguation) , computer network , philosophy , epistemology , human–computer interaction
The AOP-Wiki is the main platform for the development and storage of adverse outcome pathways (AOPs). These AOPs describe mechanistic information about toxicodynamic processes and can be used to develop effective risk assessment strategies. However, it is challenging to automatically and systematically parse, filter, and use its contents. We explored solutions to better structure the AOP-Wiki content, and to link it with chemical and biological resources. Together, this allows more detailed exploration, which can be automated.