Open AccessCharacterization of Novel Human Immortalized Thyroid Follicular Epithelial Cell Lines
Author(s) -
Kristen Hopperstad,
Theresa Truschel,
Tom Wahlicht,
Wendy Stewart,
Andrew Eicher,
Tobias May,
Chad Deisenroth
Publication year - 2021
Publication title -
applied in vitro toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 9
eISSN - 2332-1539
pISSN - 2332-1512
DOI - 10.1089/aivt.2020.0027
Subject(s) - follicular phase , follicular cell , thyroid , cell culture , epithelium , biology , medicine , pathology , genetics
Investigation of normal human thyroid function using in vitro culture systems is dependent on cells that recapitulate physiology of differentiated thyrocytes. Primary thyrocytes retain features of the native organ but have limited lifespan in culture. Immortalized thyrocytes offer an alternative if challenges maintaining phenotypic stability can be overcome to retain functional features of primary cells.