Short Communication: Plasma Lymphocyte Activation Gene 3 and Subclinical Coronary Artery Disease in the Multicenter AIDS Cohort Study | Zendy

Sudipa Sarkar | Zendy; Sabina Haberlen | Zendy; Wendy S. Post | Zendy; Theodoros Kelesidis | Zendy; Dorothy J. Wiley | Zendy; Lawrence Kingsley | Zendy; EunYoung Kim | Zendy; Frank J. Palella | Zendy; Mallory D. Witt | Zendy; Matthew J. Budoff | Zendy; Annabelle Rodríguez | Zendy; Todd T. Brown | Zendy

Open Access

Short Communication: Plasma Lymphocyte Activation Gene 3 and Subclinical Coronary Artery Disease in the Multicenter AIDS Cohort Study

Author(s) -

Sudipa Sarkar,

Sabina Haberlen,

Wendy S. Post,

Theodoros Kelesidis,

Dorothy J. Wiley,

Lawrence Kingsley,

EunYoung Kim,

Frank J. Palella,

Mallory D. Witt,

Matthew J. Budoff,

Annabelle Rodríguez,

Todd T. Brown

Publication year - 2021

Publication title -

aids research and human retroviruses

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.993

H-Index - 92

eISSN - 1931-8405

pISSN - 0889-2229

DOI - 10.1089/aid.2021.0035

Subject(s) - serostatus , multicenter aids cohort study , medicine , coronary artery disease , subclinical infection , cohort , cardiology , inflammation , population , immunology , viral load , human immunodeficiency virus (hiv) , environmental health , antiretroviral therapy

Chronic inflammation, including among people with HIV (PWH), elevates immune cell expression of lymphocyte activation gene 3 (LAG3); however, low plasma LAG3 predicts cardiovascular disease (CVD) events in the general population. The associations among LAG3 plasma levels, subclinical atherosclerosis, inflammation, and HIV infection have not been well described. We measured plasma LAG3 in 704 men with and without HIV from the multicenter AIDS cohort study, who underwent coronary computed tomography angiography. HIV serostatus was not independently associated with LAG3 after adjustment for sociodemographic and CVD risk factors. Current smoking status and African American race were associated with lower LAG3, and age and sTNFαRI concentration were associated with greater LAG3. LAG3 was not associated with coronary artery stenosis. Thus, no difference was found in plasma LAG3 concentration by HIV serostatus, and no association between LAG3 and subclinical coronary atherosclerosis in men with and without HIV was observed.

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