Open AccessShort Communication: Genetic Variation in Human IL10 Proximal Promoter and Susceptibility to HIV-1 Infection in Mali, West Africa
Author(s) -
Djeneba Dabitao,
Mamadou Dembélé,
Michael E. Urbanowski,
Bourahima Kone,
Mamadou Wague,
Nouhoum Coulibaly,
Yeya dit Sadio Sarro,
Bocar Baya,
D Goïta,
Sounkalo Dao,
Michael Belson,
Sabra L. Klein,
Chad J. Achenbach,
Jane L. Holl,
Mahamadou Diakité,
Seydou Doumbia,
Jay H. Bream,
William R. Bishai,
Souleymane Diallo,
Robert L. Murphy
Publication year - 2021
Publication title -
aids research and human retroviruses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.993
H-Index - 92
eISSN - 1931-8405
pISSN - 0889-2229
DOI - 10.1089/aid.2020.0140
Subject(s) - haplotype , single nucleotide polymorphism , biology , cohort , genetic variation , interleukin 10 , genotype , human immunodeficiency virus (hiv) , genetics , virology , immunology , demography , gene , medicine , immune system , sociology
It is now recognized that to fully understand the role of host genetic variation on susceptibility to HIV-1 infection, investigations must be extended to African populations. We sought to determine if genetic variation in IL10 are associated with HIV-1 infection in a West African cohort in Mali. HIV-infected and -uninfected individuals were genotyped for three common single nucleotide polymorphisms (SNPs) located at positions -592 (C/A), -819 (C/T), and -1082 (G/A) of the IL10 promoter. We found that the ATA haplotype, which has been previously associated with low IL-10 expression, was the most represented in the cohort. Although we observed a trend toward an increased frequency of ATA/ATA carriage in HIV-infected compared with -uninfected individuals, the difference was not statistically significant. Similarly, individual IL10 SNPs were not significantly enriched in the HIV-infected group, suggesting that IL10 genetic variants are not associated with HIV-1 in this West African cohort from Mali.