Open AccessEnhancement of mechanical properties of chitosan film by doping with sage extract-loaded niosomes
Author(s) -
Amr A. Abd-Elghany,
Ebtesam A. Mohamad,
Mohamed El-Sakhawy,
Sofiene Mansouri,
Sameh H. Ismail,
Mona S. Elneklawi
Publication year - 2022
Publication title -
materials research express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.383
H-Index - 35
ISSN - 2053-1591
DOI - 10.1088/2053-1591/ac600a
Subject(s) - chitosan , materials science , biocompatibility , ultimate tensile strength , doping , nanoparticle , niosome , composite material , chemical engineering , fourier transform infrared spectroscopy , nanotechnology , membrane , chemistry , vesicle , metallurgy , biochemistry , optoelectronics , engineering
Chitosan films are increasingly being applied in the biomedical field owing to their biocompatibility, biodegradability, non-toxicity, mucoadhesive nature, hemostatic properties, antibacterial and biological activities. This study aimed to enhance the mechanical properties of chitosan films by doping niosomal sage nanoparticles (NS-SagNPs) at various concentrations (100–300 μ g). The NS-SagNPs were prepared by a thin-film hydration process with an average particle size of 21.5 nm. The doped chitosan films were fabricated through a simple casting method. FTIR and DSC measurements confirmed the successful incorporation of NS-SagNPs in the chitosan films. The mechanical properties of the doped films were improved and the most significant improvement was found in tensile strength and elasticity when the NS-SagNPs loading was increased to 300 μ g. Based on these results, chitosan films doped with NS-SagNPs have the advantageous feature of sage and show enhanced mechanical properties compared with pure chitosan, rendering them more suitable for biomedical applications.