Open AccessDirect synthesis of substrate-independent nanoparticles for antibacterial application
Author(s) -
Wei Ye,
Nan Wang,
Lingren Wang,
Sen Liu,
Chao Zhang,
Jingjing Liu,
Xin Jiang,
Hongyan Ding
Publication year - 2021
Publication title -
materials research express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.383
H-Index - 35
ISSN - 2053-1591
DOI - 10.1088/2053-1591/ac14fd
Subject(s) - antimicrobial , carbodiimide , chemistry , substrate (aquarium) , scanning electron microscope , nanoparticle , antibacterial activity , escherichia coli , bacterial cell structure , nuclear chemistry , combinatorial chemistry , bacteria , nanotechnology , materials science , polymer chemistry , biochemistry , organic chemistry , biology , ecology , genetics , gene , composite material
In the present study, we designed a substrate-independent antimicrobial nanoparticle (SNP) via self-assembly of poly (acrylic acid) (PAA) and poly (diallyl dimethyl ammonium chloride) (PDDA). The prepared nanoparticle, with a cube structure, as revealed by scanning electron microscope (SEM), maintained structural integrity even after extensive washing. In addition, the SNP was endowed with substrate-independent adhesive affinity to various surfaces by carbodiimide reaction owing to the carboxyl group of PAA. The results of blood compatibility and cytocompatibility demonstrated that the SNP had a limited effect on blood coagulation and cell proliferation. The results of antibacterial tests indicated that the SNP exhibited significant inhibition ability for both gram-negative and gram-positive bacteria, reducing cell amount by 97.2% and 98.2% within 24 h for Escherichia coli and Staphylococcus aureus , respectively. The hemocompatibility and cytocompatibility were attributed to the introduction of carboxyl group, and the significantly antimicrobial property was ascribed to the introduction of PDDA. Furthermore, the SNP maintained outstanding long-term antimicrobial property. In general, it was believed that the designed SNP probably showed potential for applications in various biological and clinical fields.