Application of green-synthesized cerium oxide nanoparticles to treat spinal cord injury and cytotoxicity evaluation on paediatric leukaemia cells | Zendy

Yiling Wu | Zendy; Gopi Krishna Murakonda | Zendy; Ramu Jarubula | Zendy

Open Access

Application of green-synthesized cerium oxide nanoparticles to treat spinal cord injury and cytotoxicity evaluation on paediatric leukaemia cells

Author(s) -

Yiling Wu,

Gopi Krishna Murakonda,

Ramu Jarubula

Publication year - 2021

Publication title -

materials research express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.383

H-Index - 35

ISSN - 2053-1591

DOI - 10.1088/2053-1591/ac0fad

Subject(s) - cerium oxide , spinal cord injury , cytotoxicity , nanoparticle , raman spectroscopy , materials science , cerium , spinal cord , medicine , oxide , biomedical engineering , nuclear chemistry , nanotechnology , chemistry , biochemistry , physics , optics , psychiatry , metallurgy , in vitro

Injury prognosis, and treatment are one of the major objectives of nursing care during the treatment of spinal cord injury (SCI). Here, we developed a novel, biocompatible Cerium oxide nanoparticles (CeO 2 -NPs) through biosynthetic approach that can be used for the treatment of spinal cord injury in nursing care. CeO 2 -NPs were green fabricated utilizing leaf extract of Azadirachta indica . The fabricated nanoparticles still maintained the cubic-structure that was revealed by the x-ray diffraction (X-RD) analysis. Transmission electron microscopy (TEM) images displayed the sphere shape of nanoparticles having 15 nm particle size. The stretching bands of Ce–O bond were noticed at 457 cm −1 and 451 cm −1 from the Raman and Fourier-transform Infrared (FT-IR) spectra, correspondingly. On the other side, biological investigations demonstrated that the single dose application of CeO 2 -NPs at nanomolar concentration is regenerative, bio-compatible and offers a considerable neuro-protective effect on the neurons in spinal-cord of an adult rat. Neuronal function retention is showed in electro-physiological (electrography) recordings and plausibility of its uses in preventing ischemic-insult is revealed from the assay of oxidative injury. This work explored the possibility of usage of prepared CeO 2 -NPs for SCI treatment. Furthermore, examination of green fabricated CeO 2 -NPs on paediatric leukaemia (CCRF-SB) cells were found to potentiate cytotoxicity indicating their therapeutic potential for future treatment of paediatric cancer. On the other hand, the current study also highlights the potential effect of CeO 2 -NPs on treatment of SCI through nano-based therapy.

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