Practical evaluations of bioactive peptide-modified Fluorapatite/PLGA multifunctional nano-clustery composite against for root caries restorations to inhibit periodontitis-related pathogens in periodontitis care

Periodontitis noted as dental care disease, which occur the inflammatory process in the teeth tissues surrounding which has the response to bacterial accumulation. The main objectives of the present investigations were to improve the multifunctional nanocomposite with PLGA@fluorapatite and enhance the bactericidal inhibitory efficiency against periodontitis-related pathogens. The peptide modified fluorapatite@PLGA nanocomposite were synthesized and physico-chemically characterized. The observed analytical results demonstrated rod-like nanoparticles formation with favorable human cell compatibility and toxicity against bacterial pathogens. In addition, the use of FA and PLGA dual agents in the composite achieved the greatest reduction in the biofilm growth and the metabolic activity of polysaccharide production. The CFU count in the biofilms was reduced by nearly 3 orders for periodontal pathogens. Therefore, the new modified peptide PLGA-FA composite promising in the root caries restorations to inhibit periodontitis related pathogens.