A novel Ag/AgO/carboxymethyl chitosan bacteriostatic hydrogel for drug delivery | Zendy

Yanqin Xu | Zendy; Jie Liu | Zendy; Shumin Guan | Zendy; Aotong Dong | Zendy; Yuan Cao | Zendy; Changguo Chen | Zendy

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A novel Ag/AgO/carboxymethyl chitosan bacteriostatic hydrogel for drug delivery

Author(s) -

Yanqin Xu,

Jie Liu,

Shumin Guan,

Aotong Dong,

Yuan Cao,

Changguo Chen

Publication year - 2020

Publication title -

materials research express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.383

H-Index - 35

ISSN - 2053-1591

DOI - 10.1088/2053-1591/aba5cd

Subject(s) - self healing hydrogels , swelling , chitosan , drug delivery , chemistry , nuclear chemistry , drug carrier , precipitation , polymer chemistry , chemical engineering , organic chemistry , physics , meteorology , engineering

pH-sensitive Ag/AgO/carboxymethyl chitosan (CMCS) bacteriostatic hydrogels and Ag/AgO/CMCS/Aspirin (ASP) carrier hydrogels were prepared by Ag/AgO in situ precipitation method, and the effects of swelling, degradation, drug release and antibacterial properties of hydrogels were studied. The network of Ag/AgO/CMCS/ASP drug-loaded gels produced was mainly cross-linking by hydrogen bonding and intermolecular forces, and the cross-linking silver was mainly present in the elemental Ag and Ag 2+ states. Under the condition of buffer solution pH = 7.4, the cumulative release amount of Ag/AgO/CMCS/ASP drug-loaded gel was 75.20% within 12 h, and the inhibition rate of Gram-negative Escherichia coli ( E. coli ) reached the maximum of 92.32%, which had broad application prospects in the medical field.

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