Open AccessSustained released Metformin microparticles for better management of type II diabetes mellitus: in-vitro studies
Author(s) -
Hina Raza,
Sadaf Javeria,
Zermina Rashid
Publication year - 2020
Publication title -
materials research express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.383
H-Index - 35
ISSN - 2053-1591
DOI - 10.1088/2053-1591/ab6c0f
Subject(s) - ethyl cellulose , particle size , polymer , microparticle , polyethylene glycol , materials science , fourier transform infrared spectroscopy , chemical engineering , drug delivery , dissolution , peg ratio , metformin , solvent , chemistry , nuclear chemistry , nanotechnology , organic chemistry , diabetes mellitus , composite material , medicine , finance , endocrinology , engineering , economics
This work investigates Ethyl cellulose (EC) and polyethylene glycol (PEG) microparticles for prolonged delivery of Metformin HCl.The microparticles were synthesised by emulsion solvent evaporation technique; characterized for encapsulation efficiency, particle size, flow properties, surface morphology, FTIR, PXRD and drug release pattern; and investigated for the effect of formulation parameters like EC:PEG ratio, drug to polymers ratio and stirring speed on various properties of the microparticles. The drug entrapment efficiency, percent yield, particle size and drug release behaviour were found to be influenced by various formulation parameters.SEM images and size analysis confirmed formation of spherical shaped microparticles, with slightly rough surface and good flowability. FTIR revealed absence of any drug-polymer interaction and PXRD confirmed the molecular dispersion of drug with in microparticles. All the formulations showed sustained drug release pattern at pH 6.8, up to 91.34% ±1.68 metformin was released in 12 h with fickian diffusion mechanism. The designed microparticles could possibly be advantageous in terms of prolonged release, to achieve reduced dose frequency and improved patient compliance.