Open AccessFlacourtia indica based biogenic nanoparticles: development, characterization, and bioactivity against wound associated pathogens
Author(s) -
Farooq Ahmad,
Muhammad Babar Taj,
Muhammad Ramzan,
Ahmad Raheel,
Saima Shabbir,
Muhammad Imran,
Hafiz M.N. Iqbal
Publication year - 2020
Publication title -
materials research express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.383
H-Index - 35
ISSN - 2053-1591
DOI - 10.1088/2053-1591/ab6123
Subject(s) - biofilm , context (archaeology) , silver nanoparticle , fourier transform infrared spectroscopy , agar , nanoparticle , transmission electron microscopy , nuclear chemistry , nanotechnology , scanning electron microscope , antimicrobial , surface modification , agar plate , chemistry , agar diffusion test , materials science , bacteria , microbiology and biotechnology , antibacterial activity , chemical engineering , biology , paleontology , genetics , engineering , composite material
Surface engineered nanoparticles (NPs) are of great attention due to their targeted medical applications. The nature of the functionalized surface plays a vital role in achieving the required functionalities of engineered NPs. Owing to the biofilm formation capabilities of wound associated pathogens, impaired wound healing is a major complication in the medical field. In this context, herein, we report the biogenic synthesis of Flacourtia indica (FI) based NPs, i.e., FI-AgNPs using the aqueous leaf extract of this anti-bacterial herb. The newly developed FI-AgNPs were characterized using various analytical and imaging techniques such as UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The FI-AgNPs showed potent anti-microbial activity and anti-biofilm potential which were examined through a test tube adherence method and congo red agar method. It has been observed that synthesized FI-AgNPs inhibit the formation of a biofilm of observed bacteria, even at a minimum concentration of 80 μ gml −1 . These findings suggest that synthesized FI-AgNPs could be used against wound associated microbes, especially bacterial coating on medical devices, to prevent antibiotic-resistant biofilm infections. Further development and research are obligatory to decode this skill into preventive and therapeutic strategies.