Open AccessEffect of ultrasonic waves on polymorphism and crystal size distributions of mefenamic acid
Author(s) -
Siti Kholijah Abdul Mudalip,
N A Sezali,
Mohd Rushdi Abu Bakar
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/991/1/012118
Subject(s) - mefenamic acid , crystallization , sonication , polymorphism (computer science) , fourier transform infrared spectroscopy , ultrasonic sensor , fourier transform , crystal (programming language) , materials science , crystallography , analytical chemistry (journal) , chemistry , optics , chromatography , organic chemistry , physics , acoustics , biochemistry , quantum mechanics , computer science , genotype , gene , programming language
Crystallization of pharmaceutical compound that have different polymorphic forms and broad crystal size distributions remain major challenge in industry. In this present work, the potential of ultrasonic intensifications on crystallization of mefenamic acid polymorph is investigated. The effect of sonication times (5 min – 30 min) and ultrasonic powers (153.3 – 766.7 Watt) at frequency of 65 kHz on polymorphic form and crystals size distributions (CSDs) of mefenamic acid crystals during cooling crystallization were investigated using One-Factor-At-a-Time method (OFAT). The polymorphic form, CSD and shape were determined using Fourier transform infrared spectroscopy (FTIR), Malvern Mastersizer, optical microscope and X-ray diffractometry, respectively. It was found that ultrasonic power of 766.7 Watt and 30 min of sonication time produce plate-shaped crystals with the narrow CSD. The polymorph was consistent with Form I. The findings justify the suitability of ultrasonic waves to produced plate-like mefenamic acid Form I crystals with narrow CSD.