Open AccessSynthesis and Hemozoin Inhibitor of Side-Chain Modified Copper-Chloroquine Derivatives
Author(s) -
Rana A. K. Al-Refai’a,
Ahmed Ali Alkarimi
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/987/1/012021
Subject(s) - hemozoin , chloroquine , chemistry , copper , lipophilicity , nuclear chemistry , combinatorial chemistry , stereochemistry , organic chemistry , heme , malaria , enzyme , immunology , biology
This study uses copper (I) as a transition metal to improve the activity of 4-aminoquinoline as an antimalarial agent. This chloroquine derivative was synthesised and tested for in vitro antimalarial activity using a simple colourimetric method compared to the conventional purification method to measure hemozoin formation. This compound has been characterised by the combination of NMR and IR spectroscopic methods. Copper-chloroquine (Cu-CQp) might strongly exhibit antimalarial activity after showing significant inhibition of hemozoin formation compared to commercial chloroquine (CQ). This is possibly due to its lipophilicity, which enhances cell permeation. The highest activity was shown by the Cu-CQp complex in comparison to that of commercial CQ. Cu-CQp complex and CQ were used in a range of concentrations from 10–50 µM.