Open AccessElevated of Calcium and Sodium Levels as a Result of Methamphetamine Addiction, Causesand Consequence
Author(s) -
Mushtaq T. Abood,
Lamia A. Almashhedy
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/928/5/052004
Subject(s) - methamphetamine , addiction , meth , calcium , toxicity , physiology , calcium in biology , medicine , neurotransmitter , extracellular , oxidative stress , pharmacology , endocrinology , psychology , chemistry , psychiatry , central nervous system , biochemistry , monomer , organic chemistry , acrylate , polymer
Methamphetamine (METH) is an addictive drug causes toxicity and degeneration in the brain. Several evidence have demonstrated that METH toxicity results oxidative stress that regulate an intracellular signaling cascade that leads to cell death. In this paper we studied the effect of METH on calcium levels because of its great importance on human health. Calcium, is a messenger of extracellular signals in a great variety of cells; it regulates several neuronal functions, such as neurotransmitter synthesis and release, neuronal excitability, phosphorylation. Calcium is also involved in long-term processes, like memory. As well, we highlighted sodium levels to find out the main course in nerve function and to keep body fluids in balance. The study was conducted on eighty people divided into three groups, thirty non addicted men as a control group(G1), taking into account and excluding, cigarette smoking, age, social and cultural conditions, and chronic diseases, also thirty people addicted to methamphetamine(G2), and twenty people addicted to methamphetamine and other narcotic substances (mix)(G3), whose ages ranged between (15-45) years and the period of methamphetamine abuse ranged between (1-7) years. Calcium levels were highly significant in addicts group (P 0.05). Also, Calcium level were higher in METH and MIX addicts group (D3) as compared to addicts group (D1) and (D2) (P >0.05). We have noticed Increased duration of abuse Increases calcium levels. In addition to, Sodium levels were highly significant in addicts group (P 0.05). While, Sodium level were higher in MIX addicts group (A2) as compared to addicts group (A1) and (A3) (P> 0.05). As well, Sodium level were higher in METH and MIX addicts group (D2) as compared to addicts group (D1) and (D3) (P> 0.05). Indeed, the difference in the duration of the abuse affects the sodium levels.