Open AccessOne-pot four-component synthesis of phenazine derivative using 2-hydroxy-1,4-naphthoquinone
Author(s) -
Antonius Herry Cahyana,
Nisrizhifah,
Agus Rimus Liandi
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/902/1/012020
Subject(s) - phenazine , lawsone , malononitrile , chemistry , naphthoquinone , yield (engineering) , benzaldehyde , derivative (finance) , juglone , organic chemistry , quinone , combinatorial chemistry , nuclear chemistry , medicinal chemistry , catalysis , materials science , economics , financial economics , metallurgy
Phenazine is one of the most important organic compounds because of its various biological activities. This study aims to synthesize the phenazine derivatives compound using 2-hydroxy-1,4-naphthoquinone (lawsone) with a one-pot four-component method.Phenazine derivative that had been successfully synthesized was carried out by reacting four reactants at once in one flask with the same mole ratio. The reaction occurred between lawsone, o-phenylenediamine, benzaldehyde, and malononitrile. Characterization of the synthesized products was confirmed using FT-IR, UV-Vis Spectrophotometer, and LC-MS. The results of the analysis using several of these instruments obtained one compound, namely 3-amino-2-cyano-1-phenyl-1H-benzo[a]pyrano[2,3-c]phenazine. The reaction conditions were carried out at 50°C for 6 h in ethanol with unassisted catalysts and obtained a product yield of 45%.