Open AccessNickel ferrite nanocrystalline as a green and recyclable catalyst for the synthesis of Spiro-oxindole-chromene
Author(s) -
S. H. Oktavia,
Antonius Herry Cahyana,
Rika Tri Yunarti
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/902/1/012006
Subject(s) - catalysis , oxindole , nanocrystalline material , knoevenagel condensation , nickel , yield (engineering) , chemistry , environmentally friendly , organic chemistry , materials science , nanotechnology , metallurgy , ecology , biology
A separable NiFe 2 O 4 nanocrystalline catalyst was synthesized via a simple co-precipitation method. The catalytic activity of this heterogenous catalyst was investigated to synthesize Spiro-oxindole-chromene derivates via Knoevenagel condensation, and Michael addition reaction under conventional heating condition. The catalyst showed a prominent catalytic activity in a good yield (86.74 %). This easily separated catalyst could be recycled efficiently for four cycles without significant loss of its activity. Furthermore, the products were investigated for the antioxidant activity using DPPH method. The IC 50 of the compounds was found to be 182.3 ppm. The use of catalysts has been proven a simple, efficient and environmentally friendly reaction. Based on the results, it is known that the reaction could not be achieved without the presence of NiFe 2 O 4 catalyst.