Open AccessA pencil graphite electrode modified with poly nicotinamide as a framework for the electrochemical detection of propranolol hydrochloride
Author(s) -
A. Santhy,
S. Beena,
U. S. Krishnanunni Namboothiri,
S. Anupriya,
C. V. Sreeranjini
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/872/1/012125
Subject(s) - electrode , cyclic voltammetry , materials science , propranolol hydrochloride , electrolyte , electrochemistry , hydrochloride , nicotinamide , electrochemical gas sensor , differential pulse voltammetry , pencil (optics) , supporting electrolyte , analytical chemistry (journal) , chemistry , chromatography , propranolol , organic chemistry , medicine , mechanical engineering , engineering , enzyme
Herein, a novel polymer film modified pencil graphite electrode as an electrochemical sensor for the propranolol hydrochloride (PROP) is reported. A poly nicotinamide modified pencil graphite (Poly-NA-PGE) electrode was used for the electrochemical detection of propranolol hydrochloride using differential pulse voltammetry. The modified electrode was characterized by Scanning Electron Microscopy. Furthermore, the experimental parameters like pH of the supporting electrolyte, concentration of the nicotinamide and polymerisation cycles were optimized. The cyclic voltammetry of propranolol hydrochloride showcased an irreversible oxidation peak at 0.9361V. The sensor showed a linear range from 1μM - 20μM with a correlation co-efficient of 0.99825. The repeatability of the electrode was excellent with an RSD of 3.5%. The sensor was utilized effectually for the determination of propranolol from the commercially available pharmaceutical tablet.