Open AccessSilver nanocomposites based on copolymers of N,N-diallyl-N’-acylhydrazines with N-vinylpyrrolidone
Author(s) -
М. Н. Горбунова,
Т. Д. Батуева
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/848/1/012022
Subject(s) - copolymer , n vinylpyrrolidone , materials science , nanocomposite , nuclear chemistry , camptothecin , polymer chemistry , chemistry , polymer , nanotechnology , organic chemistry , composite material
New nanocomposites based on Ag and copolymers of N -vinylpyrrolidone with N, N-diallyl-N’-acetylhydrazine [poly(VP-DAAH)], N, N-diallyl-N’-butanoylhydrazine [poly(VP-DABH)] and N, N-diallyl-N’-benzoylhydrazine [poly(VP-DABEH)] have been developed. The average silver particle size ranged from 10 to 20 nm for poly(VP-DAAH), from 13 to 21 nm for poly(VP-DABEH) and from 30 to 42 nm for poly(VP-DABH), with the corresponding UV-vis absorption peak position at 400-410 nm. New nanocomposites based on copolymers of N, N-diallyl-N’-acylhydrazines have cytotoxic activity against rhabdomyosarcoma RD and melanoma MS. This effect is comparable to the activity of camptothecin, an alkaloid with high antitumor activity.