Open AccessVoltammetric Determination of Paracetamol using Polyvinyl Alcohol (PVA)-Fe3O4Modified Glassy Carbon Electrode
Author(s) -
Robi’atul Andawiyah,
Ani Mulyasuryani,
Hermin Sulistyarti
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/833/1/012059
Subject(s) - polyvinyl alcohol , horizontal scan rate , electrode , supporting electrolyte , differential pulse voltammetry , analytical chemistry (journal) , detection limit , membrane , electrolyte , cyclic voltammetry , voltammetry , nuclear chemistry , materials science , chemistry , chromatography , electrochemistry , composite material , biochemistry
Modifications of glassy carbon electrodes (GCE) as working electrodes have been carried out by polyvinyl alcohol (PVA)-Fe 3 O 4 membranes. The PVA-Fe 3 O 4 membrane was superimposed on the surface of a glassy carbon electrode. This study influences the percentage of paracetamol in the membrane, the effect of modulation time, the effect of modulation amplitude, the effect of scan rate, the effect of pH and supporting electrolytes. The performance evaluation of the modified electrode was based on a voltammogram of cyclic voltammetry (CV) and the analysis was carried out with a differential pulse voltammetry (DPV) method. The effect of pH was studied in the range of 2-7 by Britton – Robinson buffer. The results showed that the percentage of paracetamol in the membrane affected the diffusion of current. The best performance of GCE modified was produced by a membrane with paracetamol percentage of 3% (w/w). The optimum operational condition of the instrument was at modulation amplitude of 10 mV, the modulation time of 0.1 s and the scan rate of 12.5 mV/s. pH affects the shift of the anodic peak of paracetamol in a more negative direction. The results of the analysis of paracetamol using DPV method showed that more sensitivity was achieved when phosphate buffer as a supporting electrolyte was used. The sensitivity of the GCE modified by the PVA-Fe 3 O 4 membrane was 0.2922 µA/µM in the linear concentration range of 0-100 µM and limit of detection (LoD) of 8 µM.