Open AccessDynamic simulation of insulin-glucose interaction in type 1 diabetes with MATLAB Simulink®
Author(s) -
Muhammad Mufti Azis,
Jonas Kristanto,
Sarto Sarto
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/778/1/012147
Subject(s) - insulin , diabetes mellitus , artificial pancreas , type 2 diabetes , linearization , matlab , type 1 diabetes , interaction model , computer science , insulin pump , medicine , endocrinology , simulation , control theory (sociology) , physics , control (management) , artificial intelligence , nonlinear system , quantum mechanics , world wide web , operating system
Diabetes is a complex multifactorial disease where a person endures hyperglycemia in a long period. There have been large interest to perform dynamic simulation of insulin-glucose interaction to obtain a new insight of glucose homeostasis in a diabetic patient. Type 1 diabetes is characterized by the inability of β-cell in the pancreas to produce insulin and hence type 1 diabetes patient needs continuous insulin injection throughout their lives. Here, an educational module for process control in chemical engineering education has been developed to describe the insulin-glucose interaction. The model used an extended version of the minimal model (Bergman model) to simulate the interaction of insulin-glucose using state-space and SIMULINK. The state-space model development through classic linearization method followed by open-loop as well as a closed-loop simulation in SIMULINK was presented. The model was then used to simulate the meal disturbance over 24 h of simulation time. Various PI parameters were compared based on ITAE tuning methods in order to evaluate the dynamics of insulin-glucose interaction.