Open AccessMesoporous silica nanoparticles as vehicles for drug delivery
Author(s) -
I Made Adristya,
Ayu Dhea Suryaningtyas,
Jenifer Wijaya,
Felisia Cahyani Pangestu,
Sandy Budi Hartono,
L H Soewignyo,
Wenny Irawaty
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.179
H-Index - 26
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/778/1/012021
Subject(s) - mesoporous silica , rifampicin , nanoparticle , adsorption , mesoporous material , chemical engineering , drug delivery , particle size , materials science , particle (ecology) , dissolution , desorption , nanotechnology , chemistry , organic chemistry , antibiotics , catalysis , biochemistry , oceanography , geology , engineering
Silica-based materials such as mesoporous silica nanoparticle MCM-41 and hollow mesoporous silica have been synthesized at room temperature. Several characterization techniques such as N 2 adsorption-desorption analysis, SEM and FTIR have been employed to assess the formation of the nanoparticles. Rifampicin, commonly used in tuberculosis treatment, was selected as the target drug to assess the ability of the two nanoparticles to host this antibiotic. Following the loading of rifampicin on the particle surface, the dissolution behaviour of rifampicin in a media was investigated. Surface characterizations show HMS exhibits higher surface area as well as pore size and volume compared to MCM-41. However, rifampicin was not attached on the latter particles until it was modified with APTES. HMS particles store more rifampicin molecules on the particle surface than the modified MCM-41. The in-vitro drug release was investigated with buffer phosphate (pH=7.4) and the results shown that the rifampicin-loaded HMS particles were capable of releasing 18% rifampicin content after 77 h. Further investigation was necessary to support the promising application of mesoporous silica nanoparticles for pulmonary drug delivery.