Open AccessOptimization of Preparation Method of Molecularly Imprinted Microspheres by Uniform Design
Author(s) -
Qiang Zhou,
Hong Zou,
Yanhong Wang
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/774/1/012032
Subject(s) - ethylene glycol dimethacrylate , methacrylic acid , carbofuran , polymerization , particle size , molecularly imprinted polymer , materials science , dispersant , adsorption , dibutyl phthalate , chemical engineering , self healing hydrogels , polyvinyl alcohol , chromatography , chemistry , selectivity , polymer , polymer chemistry , organic chemistry , composite material , dispersion (optics) , catalysis , physics , engineering , optics , pesticide , agronomy , biology
This work presented a simple and effective method for the preparation of molecularly imprinted microspheres (MIMPs) through multi-step swelling polymerization. To prepare carbofuran MIMP with a uniform size, the experiment of optimizing the dosage of reagents which used during synthesis based on uniform design (UD) method was performed. Six kinds of factors, namely methacrylic acid (MAA, functional monomer), ethylene glycol dimethacrylate (EGDMA, cross linker), polyvinyl alcohol (PVA, dispersant), dibutyl phthalate (DBP, sweller), polymerization temperature and polymerization speed were taken into account based on UD to perform the optimization experiment. The micromorphology of MIMP was characterized by scanning electron microscopy (SEM) and it showed that the particle sizes were between 6-8 μm. The results indicated that MIMP possessed good selectivity and specificity for carbofuran, which was an excellent material for adsorption and testing of carbofuran residues in food and environment.