Preparation of polyacrylic acid and its activation on macrophages | Zendy

Mengmeng Zhou | Zendy; Xin Li | Zendy; Zhengzheng Wang | Zendy; Haijun Zhou | Zendy; Xiaoqi Chen | Zendy; Shulan Yang | Zendy; Yantao Li | Zendy

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Preparation of polyacrylic acid and its activation on macrophages

Author(s) -

Mengmeng Zhou,

Xin Li,

Zhengzheng Wang,

Haijun Zhou,

Xiaoqi Chen,

Shulan Yang,

Yantao Li

Publication year - 2020

Publication title -

iop conference series materials science and engineering

Language(s) - English

Resource type - Journals

eISSN - 1757-899X

pISSN - 1757-8981

DOI - 10.1088/1757-899x/772/1/012082

Subject(s) - polyacrylic acid , adjuvant , aqueous solution , chemistry , catalysis , ovalbumin , viscometer , polymerization , polymer , nuclear chemistry , polymer chemistry , biochemistry , materials science , organic chemistry , viscosity , immunology , biology , antigen , composite material

With the rapid and efficient development of animal husbandry industry, intensive a nd large-scale has become the main body, and the corresponding use of vaccines and vaccine adjuvants has gradually increased. Polyacrylic acid has been widely used in vaccine adjuvants because of its safety and low toxicity. In this paper, polyacrylic acid was been prepared by aqueous solution polymerization, taking redox system as catalyst. The molecular structure of polymer was characterized by FT-IR. Viscosity average molecular weight was tested on a ubbelohde viscometer. Moreover, activation of polyacrylic acid on macrophages was analyzed by cell culture method. Results showed that the vaccine prepared by polyacrylic acid as adjuvant and chicken ovalbumin could stimulate macrophages to produce higher IL-1 β.

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