Open AccessLabel free detection of uric acid using Si nanowire PH sensor
Author(s) -
Suhua Lin,
Jing Wang,
Yilin Lin,
Xiaohua Wang
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/768/2/022001
Subject(s) - nanowire , silicon nanowires , biosensor , silicon , uric acid , materials science , linearity , sensitivity (control systems) , nanotechnology , optoelectronics , chemistry , electronic engineering , biochemistry , engineering
In this study, we successfully apply a silicon nanowire FETs biosensor for detection of uric acid according to pH change. The pH sensing experiments of the silicon nanowire FETs shows that average sensitivity of 42mV/pH. We show that silicon nanowire FETs configured as pH sensors can be used for the quantitative detection of uric acid at concentration as low as 2.4mg/dL. The sensor shows a good linearity (R2 = 0.99) and sensitivity (60mV/mM) in the concentration range of 3-8mg/dL, with less than 300 sec response time. These results demonstrate that silicon nanowire FETs based biosensor can potentially be served as the diagnosis tool for general clinical examinations.