Open AccessAn efficient one-pot multicomponent synthesis of 1,4-dihydropyridines catalyzed by guanidine hydrochloride
Author(s) -
Antonius Herry Cahyana,
Bayu Ardiansah,
N. R. Aisy
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/763/1/012048
Subject(s) - guanidine , hydrochloride , ammonium acetate , chemistry , yield (engineering) , ethyl acetoacetate , aldehyde , ethanol , catalysis , organic chemistry , high performance liquid chromatography , materials science , metallurgy
Guanidine hydrochloride has been successfully used in one-pot three component assembly of aromatic aldehyde, ethyl acetoacetate and ammonium acetate to produce 1,4-dihydropyridines. Optimization of reaction conditions revealed that 10 mol% guanidine at room temperature for 4 h in ethanol is the best condition for synthesis of compound 4a in 85 % yield. Furthermore, compound 4b was synthesized and obtained in 62 %.