Open AccessCrude glycerol from waste cooking oil treatment as an alternative solvent in synthesis of diethyl-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
Author(s) -
Antonius Herry Cahyana,
Bayu Ardiansah,
H. Hanifah
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/763/1/012016
Subject(s) - glycerol , chemistry , solvent , yield (engineering) , organic chemistry , ammonium acetate , ethyl acetoacetate , derivative (finance) , benzaldehyde , nuclear chemistry , dihydropyridine , catalysis , materials science , calcium , high performance liquid chromatography , economics , financial economics , metallurgy
Diethyl-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate, a 1,4-DHP derivative, has been synthesized from benzaldehyde, ethyl acetoacetate and ammonium acetate via a one-pot three component reaction in crude glycerol as solvent. Crude glycerol was obtained from the treatment of waste cooking oil. The product was obtained in 69 % yield when the reaction was conducted at 90 °C for 1 h under reflux in 10 mL glycerol.