Open AccessSize effect of gold nanospheres on the photoacoustic imaging of cancerous cells
Author(s) -
H. Awad,
T. Abdallah,
S. Negm,
H. Talaat
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/762/1/012004
Subject(s) - pegylation , colloidal gold , photoacoustic imaging in biomedicine , particle size , nanoparticle , chemistry , materials science , biophysics , nanotechnology , biomedical engineering , optics , medicine , biochemistry , physics , polyethylene glycol , biology
The size effect of gold nanospheres (AuNS) used as a contrast agent for the photoacoustic imaging (PAI) of breast cancer cell line MDA-MB-231 have been assessed for three different sizes and at four optical densities (ODs). The decrease in the AuNS size at the same OD results in an improved PA signal. The PA signal generally increases linearly with increasing OD, with almost the same rate of increase for the three used particle sizes. It is shown that PEGylation of gold nanoparticles (AuNP) decreases the uptake of the particles by the cancerous cell therefore diminishes the PA images whereas clear images are obtained in the case of unPEGylated AuNPs.