Open AccessQuantitative determination of Lisinopril Dihydrate in pharmaceutical preparations by direct potentiometriy
Author(s) -
Stanislav Bozhanov,
Miglena Smerikarova,
Vania Maslarska
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/729/1/012059
Subject(s) - lisinopril , potentiometric titration , chemistry , ionic strength , chromatography , electroanalytical method , titration , aqueous solution , quantitative analysis (chemistry) , analytical chemistry (journal) , inorganic chemistry , ion , organic chemistry , medicine , blood pressure , angiotensin converting enzyme , radiology
A direct potentiometric titration method was applied for determination of Lisinopril Dihydrate. The method was based on the treatment of the primary data with nonlinear regression procedure. An accessible and easy-to-use algorithm for the evaluation (quantification) of a system with acid-base properties has been developed to provide a quick and unambiguous answer for the quantitative content of Lisinopril Dihydrate. The acid-base constants of Lisinopril Dihydrate were determined in aqueous solutions (at constant ionic strength 0.2 mol/l KCl and temperature 25°C). The potentiometric method developed was validated according to ICH and shows very good accuracy and precision. The present approach can be successfully used in routine analysis of the drug in quality control laboratories.