Open AccessPreparation of pesticide microspheres based on polylactic acid: optimized by response surface methodology
Author(s) -
Yan Li,
Jiakun Dai,
Duanlin Cao,
Yu Ma,
Lisha Zhen,
Fan Chang
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/711/1/012026
Subject(s) - polylactic acid , microsphere , materials science , particle size , biocompatibility , particle size distribution , biodegradation , environmentally friendly , response surface methodology , lactic acid , chemical engineering , composite material , chromatography , polymer , chemistry , organic chemistry , ecology , genetics , bacteria , engineering , metallurgy , biology
Polylactic acid, as a kind of environment-friendly material, has excellent biodegradability, biocompatibility and plasticity. In recent years, it has been widely used in medicine, packaging and other fields, but rarely in agriculture. In this study, the process of buprofezin - polylactic acid microsphere was optimized by response surface method. Changing parameters, especially the concentration of PLA and the PLA/drug ratio, can increase the encapsulation efficiency of buprofezin - PLA microspheres. Ultimately, the highest encapsulation efficiency reached to 96.47%. The result of FESEM and laser particle size distribution analyzer showed that the microspheres have smooth surface and good dispersion, with particle size of 34.2 μm.