Open AccessThe SPM study of oligonucleotides consisting of repeated nucleotide sequences
Author(s) -
Т. И. Шарипов,
Р.Р. Гарафутдинов,
I. T. Amangulova,
Р. З. Бахтизин
Publication year - 2019
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/699/1/012045
Subject(s) - oligonucleotide , nucleotide , molecule , dna , materials science , nanotechnology , conductivity , biophysics , chemical physics , analytical chemistry (journal) , biological system , chemistry , biology , biochemistry , gene , chromatography , organic chemistry
Recently, the study of the dependence of the physical characteristics of DNA molecules on their structure has become of considerable interest. Various methods are used to conduct such research, among which scanning probe microscopy (SPM) is becoming increasingly important. In this work, the short single-stranded DNA molecules consisting of dC nucleotides are visualized and their conductivity is investigated by SPM methods. It has turned out that the distribution of DNA molecules on the surface of the substrates is uniform. The measured current-voltage characteristics have made it possible to estimate the differential electrical resistance of individual d(C) 12 molecules.