Open AccessPreparation of Sustained Release Mixture Aerogel Antibacterial Agent
Author(s) -
Xiaowei Guo,
Nanchun Chen,
Xiangjian Meng,
Xiuli Wang,
Yuyan Li,
Xie Quan
Publication year - 2019
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/678/1/012115
Subject(s) - carboxymethyl cellulose , zeolite , potassium , chitosan , nuclear chemistry , swelling , antibacterial activity , drug delivery , materials science , fourier transform infrared spectroscopy , aerogel , chemistry , chemical engineering , sodium , organic chemistry , catalysis , bacteria , nanotechnology , composite material , biology , engineering , genetics
In this study, Hybrid aerogels of chitosan (CS), carboxymethyl cellulose (CMC) and Zeolite P molecular sieve (zeolite P) are successfully prepared by using Calcium chloride as the Chelator. pH-controlled drug delivery with CS/CMC/Ca 2+ /Zeolite P as the carrier is investigated using antibacterial agents potassium diformate (KDF), as the model drug. CS and CMC have pH sensitivity. The Zeolite Phas a large specific surface area which contributes to the enhancement of drug-loading amount. Thus, the synthesized microparticles were characterized by FTIR and XRD, and study the surface morphology of particles by SEM. The swelling and in vitro antibacterial activity of the prepared composites were studied. The particle systems developed are promising for adjusting the pH of the intestine and modulate gut microbiota in the intestinal tract with the purpose of improving piglets health.