Open AccessPreparation and Characterization of Magnetic Gd3+Doped Hydroxyapatite Nanoparticles
Author(s) -
Zhuozhi Ruan,
Xiaojun Zhang,
Qingguo Xing,
Yingchao Han
Publication year - 2019
Publication title -
iop conference series materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/678/1/012006
Subject(s) - coprecipitation , gadolinium , crystallinity , magnetization , doping , materials science , nanoparticle , biocompatibility , nuclear magnetic resonance , nuclear chemistry , nanotechnology , chemical engineering , analytical chemistry (journal) , chemistry , inorganic chemistry , composite material , metallurgy , organic chemistry , magnetic field , physics , optoelectronics , quantum mechanics , engineering
Hydroxyapatite (HAP), the major inorganic composition of mammal bones, has good biocompatibility, biological activity and osteoconductivity. Gadolinium(Gd) with seven unpaired electron on 4f orbit can be used for MRI contrast agent due to its large electron spin magnetic moment and relaxivity. In this study, the magnetic Gd 3+ doped HAP nanoparticles (Gd-nHAP) were synthesized via coprecipitation method. Results showed that the magnetization of Gd-nHAP was gradually enhanced along with the increase of doping content of Gd 3+ , which indicated magnetic property depended on doping content. Moreover, with a fixed doping content of Gd 3+ , the increase of reaction temperature (60°C-280°C) did not generate significant effect on magnetization of synthesized Gd-nHAP. The result showed that magnetization of Gd 3+ has no strong correlation with crystallinity and crystalline size of HAP.
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