Open AccessSynthesis of 1-methyl-3-(5-nitropyridin-2-yl) urea
Author(s) -
Binliang Zhang,
Luogen Lai,
Feng Pan,
Shan Xu
Publication year - 2019
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/677/2/022074
Subject(s) - urea , yield (engineering) , nucleophile , chemistry , molecule , proton nmr , combinatorial chemistry , organic chemistry , medicinal chemistry , materials science , catalysis , metallurgy
1-methyl-3-(5-nitropyridin-2-yl) urea ( 8 ) is an important intermediate for small molecule anticancer drugs. A rapid and high yield synthetic method for 1-methyl-3-(5-nitropyridin-2-yl) urea ( 8 ) was established in this work. The target compound was synthesized from the commercially available 2-chloro-5 -nitropyridine ( 5 ) through multi-step nucleophilic reactions.The structure of the target product was confirmed by 1 H NMR. In addition, the synthetic method was optimized. The total yield of the four steps was high up to 92%.