Open AccessSynthesis of Pyridinium Pyrimidines C-Met Small Molecule Inhibitors
Author(s) -
Hehua Xiong,
Peng Fu,
Fajuan Tian,
Qidong Tang,
Pengwu Zheng
Publication year - 2019
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/677/2/022073
Subject(s) - pyridinium , small molecule , pyrimidine , cancer , chemistry , molecule , cancer cell , cancer research , pharmacology , biochemistry , combinatorial chemistry , biology , medicinal chemistry , genetics , organic chemistry
Cancer has gradually become a serious threat to human health, and molecular targeted therapy has largely broken through the shortcomings of traditional treatment methods. C-met has been found to be overexpressed in a variety of cancer cells, and inhibition of its signaling pathway can effectively inhibit the occurrence of cancer. To explore the structure-activity relationship of the pyridinium pyrimidine cmet small molecule inhibitors, we synthesized the final compound A.