Open AccessSynthesis of Ethyl 4-(4-Nitrophenoxy) Picolinate
Author(s) -
Hehua Xiong,
Yanli Gao,
Qi Yang,
Qidong Tang,
Pengwu Zheng
Publication year - 2019
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/677/2/022072
Subject(s) - chemistry , yield (engineering) , chloride , proton nmr , combinatorial chemistry , organic chemistry , materials science , metallurgy
Ethyl 4-(4-nitrophenoxy) picolinate 4 is an important intermediate for the synthesis of many biologically active compounds. The compound ethyl 4-(4-nitrophenoxy) picolinate was obtained by three simple steps to synthesis from 2-picoliniacid. In this paper, three novel chloropicolinoyl chloride derivatives were prepared. The structure was confirmed by MS and 1 H NMR. Furthermore, the synthetic method was optimized. The total yield of the target product was 78.57%.