Open AccessPreparation and characterization of catechol-functionalized chitosan thermosensitive hydrogels
Author(s) -
D. Y. Zhang,
Hu Zhang,
Sitong Lu,
Shuozi Li,
Zechuan Yang,
P. W. Li
Publication year - 2019
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/629/1/012038
Subject(s) - self healing hydrogels , chitosan , catechol , surface modification , fourier transform infrared spectroscopy , polymer chemistry , chemistry , rheology , chemical engineering , materials science , organic chemistry , composite material , engineering
Catechol functionalization of chitosan was modified by EDC coupling reaction and then catechol-functionalized chitosan thermosensitive hydrogels were prepared by catechol-functionalization of chitosan with β-glycerophosphate disodium as a thermosensitizer. The hydrogels were then characterized by FTIR, 1 H-NMR, SEM and rheology analysis. The results demonstrated that the thermosensitive hydrogels were prepared at 37°C within several minutes by mixing 2% catechol-functionalized chitosan with 30% β-glycerophosphate disodium at a ratio of 8:2, and these thermosensitive hydrogels with porous network structure were expected to be developed as biomedical materials with wide applications.