Open AccessSynthesis, characterization and bioactivities of the new 3-acetyl-2,5-disubstituted-1,3,4-oxadiazolines
Author(s) -
Jie Zhang,
Qiang Gen-rong,
Tianhua Shen,
Lifang Pan,
Lijuan Xu,
Qingbao Song
Publication year - 2019
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/612/2/022049
Subject(s) - staphylococcus aureus , reverse transcriptase , acetic anhydride , human immunodeficiency virus (hiv) , chemistry , elemental analysis , carbon 13 nmr , combinatorial chemistry , stereochemistry , organic chemistry , bacteria , biochemistry , biology , virology , rna , gene , genetics , catalysis
A series of heterocyclic compounds 3-acetyl-2,5-disubstituted-1,3,4-oxadiazolines (2a-2g) were prepared with hydrazones and acetic anhydride. The products were characterized by 1 H-NMR, 13 CNMR, IR and elemental analysis. Furthermore, these compounds were tested for their bioactivities of anti-Staphylococcus aureus, HIV-1 RT (Human Immunodeficiency Virus Type 1 Reverse Transcriptase) and proliferative. However, there were no compounds showed promising activities with S. aureus, HIV-1 RT, HT-29 cells and HT-1080 cells.