Open AccessThe Neurotoxicity of Ethanol and The Underlining Mechanisms
Author(s) -
Shasha Du,
Huahua Shi,
Yan Zhao
Publication year - 2019
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/612/2/022028
Subject(s) - neurotoxicity , overconsumption , ethanol , neurocognitive , alcohol , ingestion , brain function , chemistry , physiology , alcohol abuse , medicine , pharmacology , neuroscience , toxicity , biochemistry , biology , psychiatry , cognition , production (economics) , economics , macroeconomics
After ingestion, ethanol is mainly metabolized in the liver, eventually producing ATP and end products such as carbon dioxide and water. Because it is both water- and fat-soluble, it is easy to pass through the blood-brain barrier and affect the function of the nervous system. Overconsumption of alcohol or alcohol abuse is associated with various diseases including neurocognitive disorders. This article reviews the neurotoxicity of ethanol and discusses its possible molecular mechanisms.