Open AccessSolubility characteristics of the material based on porous hydroxyapatite ceramics coated with PLGA
Author(s) -
Daria Lytkina,
Anastasiya Gutsalova,
Maxim A. Pozdniakov,
Lothar Heinrich,
В. В. Козик
Publication year - 2019
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/597/1/012006
Subject(s) - dissolution , porosity , materials science , coating , plga , diffusion , solubility , ceramic , composite material , solvent , chemical engineering , chemistry , nanotechnology , organic chemistry , physics , nanoparticle , engineering , thermodynamics
Composites based on a porous hydroxyapatite carcass with a coating of PLGA were obtained. According to the SEM images, it was found that, the composites had a different coating character depending on the porosity of the HA framework. After 1 week, the dissolution rate of composites increases relative to pure PLGA, and the growth is proportional to the increasing of the amount of pore-forming agent in the material by 20-50%. The dissolution rate of HA in the composition of materials also increases since the second week, because the diffusion of the solvent in the HA increases as the result of PLGA hydrolysis.